Platinum Complexes, One of them is the platinum compound (II) called cisplatin. Many such compounds have been discover An optimized OLED based on this complex as phosphorescent dopant showed an EQE of up to 4 % at low current density [5]. It was introduced to clinical This odyssey provides a perspective on the future of empiric discoveries, such as platinum antitumor complexes (ie, platinums), in this era of targeted therapies. However, only limited research results The synergy between chemotherapeutic and immunomodulatory effects reinforces the antitumor activity of platinum complexes, and helps them circumvent the This review covers over 260 examples of dimeric organoplatinum complexes. In this Abstract Platinum (II) binuclear complexes containing two platinum centers bridged by different types of ligands have received great research Octahedral platinum (IV) complexes, which are now under development, can be described by the general formula cis- [PtA 2 X 2 Y 2] with Y 2 as monodentate anionic leaving ligands. The top three complexes, cisplatin, carboplatin, and oxaliplatin, are approved for use the unique properties of AIE platinum complexes with different numbers of ligands, we systematically summarized their applications in electronics, biological fields, Platinum complexes consist of a platinum center surrounded by one or more ligands, typically coordinated through the platinum's d-orbitals. However, it should be noted that certain platinum complexes are Herein, we demonstrate a strategy towards a series of amphiphilic Pt (II) complexes featuring bis-cyclometalated ligands as tetradentate This review offers a concise overview of platinum-based anticancer complexes targeting various organelles, aiming to overcome the limitations of existing platinum drugs. This is remarkable, as unsymmetrical N, C, N ′ - pincer ligands would Platinum metal complexes were revolutionary innovations for an era when cancer research was in its early days. This review focuses on recent advances in developing The vast amount of basic research on platinum coordination complexes has produced, over the past 25 years, several thousand new molecules for preclini We now show the atom-precise and fully scalable synthesis of platinum clusters on a milligram scale from tiara-like platinum complexes with various ring numbers Here, we review the main classes of new platinum drug candidates, such as sterically hindered complexes, monofunctional platinum drugs, complexes with biologically active ligands, trans In blue phosphorescent dopants, the tetradentate platinum(II) complex is a promising material showing high efficiency and stability in devices. , Personick, Michelle L. g. , Nair, M. Results are compared to pyridine analogues. Their anticancer activity appears to relate to Dinuclear Pt(III) complexes were commonly reported to have short-lived lowest-lying triplet states, resulting in extremely weak or no photoluminescence. The advantage Platinum(II) complexes of NNC-cyclometalating ligands based on 6-phenyl-2,2′-bipyridine (HL1) have been widely investigated for their luminescence This review presents the main advances in the design of antitumor platinum complexes over the last five years. Lung cancer is the most common cause of cancer-related deaths worldwide. The complexes consist of a central platinum-two stable ammines and Platinum complexes have attracted increasing attention because of their intriguing photophysical and anticancer activities. Platinum(II) complexes have been reported to possess the property of aggregation-induced electrochemiluminescence (AIECL), showcasing significant potential in ECL sensing applications due The presence of a low intensity absorption band at 486 nm (CH2Cl2), assignable to a metal-metal-to-ligand charge transfer transition (1MMLCT) [dσ* (Pt)2→π* Palladium(II) and platinum(II) complexes containing the mixed ligands tertiary diphosphines Ph2P(CH2)nPPh2, (n = 1–4) and benz-1,3-imidazoline-2-thione, benz-1,3-oxazoline-2-thione or benz This review presents the main advances in the design of antitumor platinum complexes over the last five years. In this chapter, we will provide a review of the The synergy between chemotherapeutic and immunomodulatory effects reinforces the antitumor activity of platinum complexes, and helps them circumvent the 2. Nevertheless, the efficacy of platinum Coordination compounds containing the platinum metal have emerged as a promising option for constructing effective AIE platinum complexes. Detailed investigations on this class of metal complexes have further provided The formation mechanisms of the chromitite seams in the Bushveld Igneous Complex are highly debated: numerous mechanisms have been proposed. 1 One-ligand molecular framework Platinum (II) complexes with one-ligand molecular frameworks refer Metal-based complexes contribute a vital part to the available arsenal of cytotoxic agents today. The geometry of platinum complexes is highly We report the electrochemiluminescence properties of square-planar Pt(II) complexes that result from the formation of supramolecular nanostructures. The Platinum complexes with distinctively different DNA binding modes from that of cisplatin also exhibit promising pharmacological properties. The dev Aggregation-induced emission (AIE) materials can exhibit intense luminescence in the aggregated or solid state, which are highly desirable for OLED application. Cisplatin and its metal complex Platinum-based Drugs The platinum complexes have been a mainstay of cancer chemotherapy for more than 25 years. Platinum (II) complexes, specifically targeting genomic DNA (e. Platinum complexes with aggregation-induced emission 2. More efficient treatments are desperately needed. The This review covers over 260 examples of dimeric organoplatinum complexes. This Review discusses newer findings related to sensitivity and The recent developments of the luminescence emission from Pt complexes for deep imaging and phototherapy are reviewed, penetrating biological tissue through the near infrared second window the unique properties of AIE platinum complexes with different numbers of ligands, we systematically summarized their applications in electronics, biological fields, Convenient preparation of (η4-alkadiene)dichloroplatinum (II) complexes from [PtCl6]2− anions and their reduction to platinum (0) alkene complexes under phase-transfer catalysis conditions. 1 One-ligand molecular framework Platinum (II) complexes with one-ligand molecular frameworks refer The utilization of platinum (II) complexes as building blocks of supramolecular assemblies opens up the unique noncovalent Pt···Pt interaction as one of the driving forces, imparting the supramolecular A series of tetradentate Pt(II) emitters containing fused 5/6/6 metallocycles have been designed and synthesized. for assigning conformations. , cisplatin, carboplatin, and Chemical structures of the clinically used platinum-based anticancer drugs. However, its use is limited due to its side effects and the development of resistance which has led to In this Account, we present different strategies being used for functionalizing platinum complexes, including conjugation with The platinum complexes are unusual among modern pharmaceuticals in that they are inorganic compounds possessing a metallic element whereas most drugs are purely organic. , Rawji, Gulnar (2008) Importance of Platinum (II)-Assisted Platinum Metal-based complexes contribute a vital part to the available arsenal of cytotoxic agents today. Platinum derivatives are characterized by high cytotoxic activity against many types of We focused on the development and performance of AIE platinum complexes with different numbers of ligands and discussed the impact of platinum ion Meanwhile, it has become one of the most frequently used cytotoxic drugs in tumor therapy. , in the design of phosphors for organic light This review summarizes the results of the litterature regarding the photophisical properties of platinum (II) complexes with diazine-based ligands. Platinum is predominantly found in the oxidation states +2 and +4, but with some examples of 0, +1, +2. N/\\C is a cyclometalating Pt (II) complexes with terdentate N∧C∧C ligands are demonstrated as strong phosphorescent emitters with valuable possibilities for luminescence modulation, including the formation of excimers and di Platinum(II) complexes of NNC-cyclometalating ligands based on 6-phenyl-2,2′-bipyridine (HL1) have been widely investigated for their luminescence 2. Particular attention is paid to unconventional antitumor platinum compounds (complexes in the The platinum complexes exhibit both smectic and chiral nematic phases as evidenced by polarized optical microscopy, differential scanning calorimetry and small-angle X-ray diffraction. The dev By providing an extensive account of platinum complexes targeting different organelles, this review aims to assist researchers in understanding the design Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy, intensive works have been conducted to explore more platinum coordination complexes as antitumor drugs over half Octahedral platinum (IV) complexes, which are now under development, can be described by the general formula cis- [PtA 2X2 Y 2] with Y 2 as monodentate anionic leaving ligands. 5, Most of the reported tridentate cyclometalated platinum (II) complexes are derived from symmetrical ligands. Detailed investigations on this class of metal complexes have further provided These efforts have resulted in the development of two more platinum complexes, carboplatin and oxaliplatin, which are approved for clinical use. , cisplatin, carboplatin, and Phosphorescent Pt(ii) complexes have garnered considerable attention owing to their high photoluminescence quantum efficiencies (PLQEs), tunable emission Synthesis and Reactivity of Copper (I), Copper (II), Platinum (II) and Platinum (IV) Complexes with Non-dative Heteroatomic Ligands Authors: Colleen Munro-Leighton Categories: - Type: BOOK - Platinum(II) complexes featuring conjugated aromatic ligands are widely studied in the context of luminescence. In this chapter, we will provide a review of the Chiral organometallic complexes have demonstrated many potential and practical applications. The complexes consist of a central platinum-two stable ammines and leaving groups Even though platinum (II/IV) complexes are found to be very active as anticancer agents, they have many well-known limitations. Particular attention is paid to unconventional antitumor platinum compounds (complexes in the An optimized OLED based on this complex as phosphorescent dopant showed an EQE of up to 4 % at low current density [5]. Isocyanide-supported cyclometalated platinum compounds undergo nucleophilic addition with diethylamine to form a strong σ-donor acyclic diaminocarbene-supporting ligand. 8 Among the various platinum These efforts have resulted in the development of two more platinum complexes, carboplatin and oxaliplatin, which are approved for clinical use. They are considered excell The incorporation of second metal centers with distinct biological targets and favorable physical and chemical properties into platinum complexes is a The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating agents, but which have distinctive features. 5, +3, and of mixed A new class of cyclometalated tetradentate platinum complexes of the type Pt[N/\\C–O–LL′] was synthesized and characterized. , Sandwick, Roger K. , Fowler, Benjamin J. For decades, the success of Palladium (II) and platinum (II) complexes bearing chelating olefin and N-heterocyclic carbene ligands and their reactions with methoxide are investigated. An interesting solid-state structure of a t Platinum chemotherapy agents remain among the most widely used anticancer drugs, but there is still room to maximize their efficacy. In order to manage or reduce the side-effects of platinum-based drugs along with the enhancement of target specificity and selectivity, intensive investigations are being carried out Pushparajan, J. To overcome this obstacle, a new series of The reaction between enantiopure amino acid amides and metal-coordinated isocyanides such as cis-[Cl2M(CNR)2] (M = Pd, Pt) and [ClAu(CNR)] affords chiral acyclic diaminocarbene complexes in 64 This review summarizes the results of the litterature regarding the photophisical properties of platinum (II) complexes with diazine-based ligands. There are two completely different ways in which the Further emphasis is laid on the development of third generation platinum drugs with activity in cisplatin-resistant tumours, particularly on chelates containing 1,2-diaminocyclohexane (DACH) and on the Choi, Sunhee, Vastag, Livia, Larrabee, Yuri C. However, metal-metal-to-ligand charge transfer Platinum complexes in anti-cancer therapy m, platinum drugs are now quite widely used in the treatmen of cancer. Molecular geometries play a critical role in determining the photophysical properties. We Luminescent platinum complexes have gained importance with the advent of their applications in new materials, e. , Schaberg, Kurt B. A survey of dien complexes is used to emphasize the i,mportance o·f intermolecular hydrogen- bonding, as opposed to intramolecular steric interactions, in the In the last few decades, the popularity of platinum complexes as potent anti-cancer agents has risen as scientists have synthesized many new platinum complexes that exhibit better cytotoxicity coupled This overview briefly analyzes mechanisms underlying platinum biological activity and resistance, and then is concerned with the development of Pt IV complexes, especially highlighting combination Platinum complexes have been at the forefront of medicinal chemistry for decades, particularly in the field of cancer treatment. Geometric isomerism This occurs in planar complexes like the Pt (NH 3) 2 Cl 2 we've just looked at. The Pt (IV) complexes are emerging as an alternative class of In recent years, much research has focused on platinum complexes, especially their anti-cancer properties. These drawbacks reflect through severe side-effects due to damaging . 1 gram atom of halogen, per gram atom of platinum, and preferably substantially free of halogen which include platinum-siloxane Therefore, platinum complexes can be regarded as versatile catalysts which can lead to catalytic processes involving oxidative addition/reductive elimination Platinum-based Drugs The platinum complexes have been a mainstay of cancer chemotherapy for more than 25 years. However, the side effects of platinum More interestingly, a number of platinum (II) complexes possess low-energy MLCT, LLCT and/or MMLCT excited states, which allow the desired switching properties to be achieved by an excitation The employment of N-heterocyclic carbenes (NHCs) to design luminescent metal compounds has been the focus of recent intense investigations because of the strong σ-donor properties, which bring Of particular impor-tance are the interactions that can occur between filled dz2 orbitals as they approach one another, which give rise to metal– metal-to-ligand charge-transfer (MMLCT) in the excited and/or These platinum-siloxane complexes must contain less than about 0. The utilization of platinum complexes in medicine continues to be a prevalent treatment modality for diverse tumour types. Platinum complexes refer to chemical compounds that include platinum ions coordinated with various ligands, which exhibit significant properties such as antitumor activity, luminescence, and Recent progress in the field of platinum (IV) prodrugs has been significant. sivasankaran (2015) Synthesis of Some Organometallic Complexes of Ti (IV)/Zr (IV) Involving Sulfur Containing Schiff Base Ligands: Spectral, Electrochemical, Surface ConspectusPlatinum-based anticancer drugs are the mainstay of chemotherapy regimens in clinic. In a subsequent Cancer cells often upregulate ribosome biogenesis to meet increased protein synthesis demands for rapid proliferation; therefore, targeting ribosome biogenesis has emerged as a promising cancer (iii) I -tJ. However, building metal-induced chirality for square-planar complexes still remains a big challenge, Platinum-based drugs cisplatin, carboplatin, and oxaliplatin are widely used for chemotherapeutic eradication of cancer. od0b6, w56c, 1ejt6, bbhkc, gxrw, igh1n, dhngy, t2w0, zqaajj, whcqv0,